Description

Name: MOTS-c (Mitochondrial ORF of the 12S rRNA Type-c Peptide)
Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Molecular Formula: C₂₁₅H₃₂₄N₅₆O₆₅S₂
Molecular Weight: ≈ 2170.41 g/mol
CAS Registry Number: 1334172-56-9

MOTS-c – COMPREHENSIVE RESEARCH PEPTIDE FOR MITOCHONDRIAL SIGNALING AND METABOLIC STUDIES
Scientific Overview of MOTS-c

MOTS-c is a mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA region. It is a 16-amino-acid peptide that has been identified as part of the mitochondrial retrograde signaling network, linking mitochondrial function with cellular metabolism and stress adaptation.

In in-vitro and in-vivo experimental models, MOTS-c has been studied for its regulatory and adaptive roles in cellular metabolism and mitochondrial communication. Research has explored:

• Mitochondrial–Nuclear Signaling Pathways – investigation of MOTS-c’s influence on nuclear gene expression under metabolic stress (Lee et al., 2015)
• AMPK Pathway Activation – study of energy-sensing and metabolic regulation mechanisms in experimental systems (Kim et al., 2018)
• Cellular Adaptation and Stress Response – exploration of peptide-mediated protective signaling during oxidative and metabolic challenges (Zhao et al., 2019)

MOTS-c has become a key research peptide for understanding mitochondrial peptide biology, metabolic integration, and cellular signaling across diverse physiological contexts.

*This peptide is intended solely for laboratory research use. It is not approved for human consumption or therapeutic application.

COA for this item

MOTSC COA MOT15N1125